An image of colourful houses on the shore of a Mediterranean City

P&O Cruise Deals

Mesmerising Mediterranean

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History, Beauty & Adventure

Set sail on P&O’s Mesmerising Mediterranean, where sun-drenched coastlines, ancient wonders, and mouthwatering cuisine create the ultimate voyage of discovery. From the artistic treasures of Florence to the whitewashed villages of Santorini and the lively streets of Barcelona, every stop is steeped in history and charm. Stroll through Rome’s iconic piazzas, sip a glass of wine on the French Riviera, or lose yourself in the vibrant markets of Istanbul—this is the Mediterranean at its most captivating.

Genoa - Italy
A view of the Coast of Genoa

With P&O, your Mesmerising Mediterranean adventure is as effortless as it is unforgettable. Indulge in world-class dining inspired by the regions you visit, relax in stylish accommodations, and enjoy outstanding entertainment as you cruise through these legendary waters. Whether you’re uncovering the secrets of ancient civilizations, basking in golden sunsets, or savoring the flavors of the Med, P&O ensures every moment is a delight for the senses.

Marseille - France
A landscape shot of Marseille

Amazing Holiday Deals

* Price information

Prices on display are from and per person based on 2 sharing the lowest cabin grade unless otherwise stated. Gratuities are not included in any of these offers unless otherwise stated. Baggage charge may apply. No Booking fee is payable when you book online. Cruise Nation and Cruise Line Terms & Conditions apply. E&OE.

For the latest and most up to date availability & pricing, please click on a deal or call our team on 0333 455 8500

Average Customer Rating:
4.9/5|
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Independent Service Rating based on 579 verified reviews.Read all reviews

Award

Super experience

Very knowledgeable, no upselling, more than happy to provide alternative dates/flights Very helpful

Mrs Karen Hunter Roberts-11 August 2025

Excellent service

Excellent service give them a ring it’s much easier, saved ourselves £275 from our usual cruise provider, tried a few nobody beat there price and a discount on Southampton port parking , what’s not to like .

Mr Keith McCarthy-10 August 2025

Excellent service

The lady who helped me book my holiday was patient, helpful and took the time to make sure I had what I wanted.

Mrs Karen Williams-09 August 2025

For us two 9/10 for all of us 9/10

Very good to us both and checking all. Lisa did a good job for us and we told friends and they booked onto same cruise and the total going and booked with cruise nation is ten .

Mr Stephen Symonds-09 August 2025