An image of colourful houses on the shore of a Mediterranean City

Mesmerising Mediterranean

Set sail on P&O’s Mesmerising Mediterranean, where sun-drenched coastlines, ancient wonders, and mouthwatering cuisine create the ultimate voyage of discovery. From the artistic treasures of Florence to the whitewashed villages of Santorini and the lively streets of Barcelona, every stop is steeped in history and charm. Stroll through Rome’s iconic piazzas, sip a glass of wine on the French Riviera, or lose yourself in the vibrant markets of Istanbul—this is the Mediterranean at its most captivating.

Genoa - Italy
A view of the Coast of Genoa

With P&O, your Mesmerising Mediterranean adventure is as effortless as it is unforgettable. Indulge in world-class dining inspired by the regions you visit, relax in stylish accommodations, and enjoy outstanding entertainment as you cruise through these legendary waters. Whether you’re uncovering the secrets of ancient civilizations, basking in golden sunsets, or savoring the flavors of the Med, P&O ensures every moment is a delight for the senses.

Marseille - France
A landscape shot of Marseille

Amazing Holiday Deals

* Price information

Prices on display are from and per person based on 2 sharing the lowest cabin grade unless otherwise stated. Gratuities are not included in any of these offers unless otherwise stated. Baggage charge may apply. No Booking fee is payable when you book online. Cruise Nation and Cruise Line Terms & Conditions apply. E&OE.

For the latest and most up to date availability & pricing, please click on a deal or call our team on 0333 455 8500

Average Customer Rating:
4.9/5|
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Independent Service Rating based on 11,625 verified reviews.Read all reviews

Award

Fantastic service and not pushy thank you. And wished Wrexham good luck.

Great service from Scott Very patient with me and lots of advice on trains and buses. We have never been to Canada before and he was very helpful telling us something about Canada. We are really looking forward to our cruise and stay holiday. Thank...

Mrs Karen Bishop-16 February 2026

Cruise and stay holiday

Telephone answered very quickly, very helpful , booked cruise and stay , all questioned dealt with would recommend

Mrs Judith Tebbutt-14 February 2026

Very efficient, helpful and slick.

Mrs Joanne Heather-16 February 2026

Excellservice from Scott in booking our Bucket list trip to the PanamaCanal

Excellent conversation with Scott to book our Bucket list trip to the Panama canal. He was really helpful booking our cabin and getting the exact flights and upgrades. Really appreciated his help so a big thank you!

-15 February 2026