An image of colourful houses on the shore of a Mediterranean City

Mesmerising Mediterranean

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History, Beauty & Adventure

Set sail on P&O’s Mesmerising Mediterranean, where sun-drenched coastlines, ancient wonders, and mouthwatering cuisine create the ultimate voyage of discovery. From the artistic treasures of Florence to the whitewashed villages of Santorini and the lively streets of Barcelona, every stop is steeped in history and charm. Stroll through Rome’s iconic piazzas, sip a glass of wine on the French Riviera, or lose yourself in the vibrant markets of Istanbul—this is the Mediterranean at its most captivating.

Genoa - Italy
A view of the Coast of Genoa

With P&O, your Mesmerising Mediterranean adventure is as effortless as it is unforgettable. Indulge in world-class dining inspired by the regions you visit, relax in stylish accommodations, and enjoy outstanding entertainment as you cruise through these legendary waters. Whether you’re uncovering the secrets of ancient civilizations, basking in golden sunsets, or savoring the flavors of the Med, P&O ensures every moment is a delight for the senses.

Marseille - France
A landscape shot of Marseille

Amazing Holiday Deals

* Price information

Prices on display are from and per person based on 2 sharing the lowest cabin grade unless otherwise stated. Gratuities are not included in any of these offers unless otherwise stated. Baggage charge may apply. No Booking fee is payable when you book online. Cruise Nation and Cruise Line Terms & Conditions apply. E&OE.

For the latest and most up to date availability & pricing, please click on a deal or call our team on 0333 455 8500

Average Customer Rating:
4.9/5|
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Independent Service Rating based on 11,429 verified reviews.Read all reviews

Award

All round great experience

Polite, helpful and the prices are great

Mr Martyn Paris-09 November 2025

5* service

great support from Karen - very detailed and helpful.

Mr Stephen Donald-05 November 2025

Cruise nation

Phone calls were efficient and gave all details needed but changed mind on cruise and ended up booking online as after 6pm sunday when booked

Mrs Dawn Broadley-04 November 2025

Great service!!!

Excellent communication. Speedy replies and good information. Scott was very knowledgeable and provided reply to.emails at all times!!

Mr Keith Hennelly-03 November 2025